| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | MitoParaquat |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
MitoPQ (CAS 1821370-28-8) is a research-grade small molecule supplied by TargetMol.
Alternative names: MitoParaquat
Physical Properties
| CAS Number | 1821370-28-8 |
|---|---|
| Molecular Formula | C39H46I3N2P |
| Molecular Weight | 954.48 g/mol |
| SMILES | C(N+)1=CC=C(C2=CC=(N+)(CCCCCCCCCC(P+)(C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=C… |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
MitoPQ (MitoParaquat) is a mitochondria-targeted small molecule compound that selectively enhances mitochondrial superoxide and hydrogen peroxide levels and inhibits insulin-stimulated glucose uptake and translocation of glucose transport protein 4 (GLUT4) to the plasma membrane in adipocytes and myotubes.MitoPQ can be used to MitoPQ can be used to study mitochondrial oxidative stress and regulated GLUT4 transporter.
Target(s): transporter, Glucokinase
Signaling pathway(s): Metabolism
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Sonication time depends on compound solubility and concentration. In most cases, 1–3 minutes of intermittent bath sonication is sufficient to dissolve small molecule compounds in DMSO. For poorly soluble compounds, warming the solvent to 37–50 °C combined with brief vortexing between sonication pulses can improve dissolution. If the compound remains undissolved, prepare a more dilute stock solution.
Yes — TargetMol inhibitors can be used in cell-based and in vitro experiments. Prepare a DMSO stock, then dilute into cell culture medium to the desired working concentration, keeping DMSO ≤ 0.1% (v/v) to avoid solvent toxicity. Note that not all compounds have published data for every cell line or assay system; in such cases, perform a dose-response experiment with appropriate positive and vehicle controls to validate efficacy in your specific model.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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