| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | MK 8133 |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
MK-8133 (CAS 1431472-56-8) is a research-grade small molecule supplied by TargetMol.
Alternative names: MK 8133
Physical Properties
| CAS Number | 1431472-56-8 |
|---|---|
| Molecular Formula | C23H21N5O2 |
| Molecular Weight | 399.45 g/mol |
| SMILES | C(=O)(C1=C(C=CC=C1)C=2N=CC=CN2)N3C(CH)(OC4=CC(CN)=CC=N4)CC(CH)3C |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
MK-8133 is an antagonist of orexin-2 selective receptor with favorable development properties.
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Try the following steps: (1) warm the DMSO solvent to 37–50 °C before adding the compound; (2) vortex vigorously for 30 seconds then bath-sonicate for 1–2 minutes; (3) if still undissolved, prepare a more dilute stock. Note that maximum solubility values are reference conditions — actual solubility can vary with temperature, solvent lot, and compound batch. Contact BioHippo support if dissolution problems persist.
Yes, our inhibitors can be used for animal/in vivo experiments. However, some compounds may not have literature supporting their use in animal experiments. In such cases, we cannot guarantee efficacy.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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equivalents, or discuss custom synthesis with the right QC documentation (RUO).
