| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | ML297 |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
ML 297 (CAS 1443246-62-5) is a research-grade small molecule supplied by TargetMol.
Alternative names: ML297
Physical Properties
| CAS Number | 1443246-62-5 |
|---|---|
| Molecular Formula | C17H14F2N4O |
| Molecular Weight | 328.32 g/mol |
| SMILES | N(C(NC1=CC(F)=C(F)C=C1)=O)C=2N(N=C(C)C2)C3=CC=CC=C3 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
ML 297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively). ML 297 exhibits no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels, and has minimal effect on a panel of other ion channels, receptors and transporters.
Target(s): Potassium Channel
Signaling pathway(s): Membrane transporter/Ion channel
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
It is recommended to sonicate at a lower frequency
Centrifuge the closed vial at 3000 rpm for 1–2 minutes to consolidate the powder at the bottom. For electrostatically charged powders, briefly warm the vial to room temperature and allow it to equilibrate before opening. Then add the appropriate solvent directly onto the powder and vortex before sonicating. Avoid tapping the vial vigorously, as this can generate fine powder aerosol.
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- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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