| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | ?????? |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
Moxonidine hydrochloride (CAS 75536-04-8) is a research-grade small molecule supplied by TargetMol.
Alternative names: ??????
Physical Properties
| CAS Number | 75536-04-8 |
|---|---|
| Molecular Formula | C9H13Cl2N5O |
| Molecular Weight | 278.14 g/mol |
| SMILES | Cl.ClC=1N=C(N=C(OC)C1NC2=NCCN2)C |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Moxonidine Hydrochloride serves as a selective agonist for the imidazoline receptor subtype 1 and functions as an antihypertensive agent. It primarily acts within the central nervous system and demonstrates a significant preference for I1 imidazoline receptors over alpha2-adrenoceptors, with a 40-fold higher affinity. This compound effectively reduces stimulated norepinephrine overflow, indicating its potent efficacy. Despite similar agents like AGN192403 targeting the same receptor, moxonidine's dose-response efficacy remains unaffected. Its ability to lower blood pressure and reduce heart rate is distinctly mediated through imidazoline receptors, reliant on well-preserved noradrenergic pathways within the rostral ventrolateral medulla (RVLM). This interaction is potentially linked to a specific 42 kDa imidazoline receptor protein, emphasizing its unique mechanism of action compared to other drugs like clonidine.
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
After the stock solution is prepared, it is typically stored at -80°C and can be kept for over 1 year. It is recommended to aliquot to avoid repeated freeze-thaw cycles. For frequent use, it can be stored at 4°C for over a week.
Solid-form products can be stored at -20°C for more than 3 years. Stock solutions are typically stored at -80°C and can be stored for more than 1 year. It is recommended to aliquot the product to avoid repeated freeze-thaw cycles. For short-term storage, samples can be kept at 4°C for more than one week.
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