| Field | Specification |
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| Mfr No | |
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| Host | |
| Immunogen | A synthesized peptide derived from human Mras was used as the immunogen for the MRAS antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
MRAS Antibody / Ras-related protein M-Ras is a anti-MRAS Rabbit antibody Recombinant Rabbit Monoclonal clone 29M72 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.
Key elements and design rationale
- Target: MRAS
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 29M72, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): WB
Biological background
MRAS antibody is widely applied in cancer research, developmental biology, and signaling studies. MRAS differs from classical Ras proteins in sequence and regulation, giving it distinct functions. It interacts with SHOC2 and PP1c in a complex that regulates MAPK pathway activation. MRAS also contributes to neuronal differentiation, cardiac development, and vascular biology. By detecting MRAS, researchers can investigate how this atypical Ras family protein integrates signaling across tissues.
Applications of MRAS antibody include western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects MRAS expression in cell lysates, immunohistochemistry maps its expression in tissues such as brain and heart, and immunofluorescence highlights subcellular localization at the plasma membrane and endomembranes. These methods provide powerful tools for exploring MRAS biology in normal and disease contexts.
Mutations in MRAS are rare compared to KRAS or HRAS, but dysregulated expression has been linked to cancer. MRAS activity supports cell proliferation and transformation in lung, gastric, and hematologic malignancies. It also modulates epithelial mesenchymal transition and cell migration. By applying MRAS antibody, scientists can evaluate MRAS as a potential biomarker and therapeutic target.
In cardiovascular biology, MRAS regulates vascular smooth muscle cell signaling and contributes to cardiac morphogenesis. Its expression in neuronal tissues links it to axonal guidance and synaptic plasticity. MRAS is also involved in T cell receptor signaling, suggesting roles in adaptive immunity. The antibody therefore supports research across multiple physiological systems.
Therapeutically, targeting MRAS signaling is under investigation, particularly its cooperation with SHOC2 in Ras MAPK activation. Detection of MRAS with antibody based assays provides biomarkers for drug development and pathway modulation. MRAS antibody from
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
