| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | A portion of amino acids 460-560 from the human protein was used as the immunogen for the Muellerian Inhibiting Factor antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
The transforming growth factor superfamily proteins are involved in embryonic development and adult tissue homeostasis. The Muellerian inhibiting factor (MIF), also called Muellerian-inhibiting substance (MIS) and Anti-Muellerian hormone (AMH), glycoprotein is produced by the Sertoli cells of the testes. Fetal testes produce both MIF and testosterone, the presence of which result in male offspring. Absence of MIF and testosterone in a developing fetus results in the induction of Mullerian duct differentiation, and Wolffian duct development is not induced. Testosterone induces the differentiation of the Wolffian ducts whereas MIF causes regression of the Muellerian duct. MIF inhibits the growth of tumors derived from tissues of Mullerian duct origin. It can also inhibit the autophosphorylation of the EGF receptor in vitro. Defects in anti-Muellerian hormone are the cause of persistent Muellerian duct syndrome type I (PMDS-1). PMDS-1 is a form of male pseudo hermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.
This anti-Muellerian Inhibiting Factor antibody is supplied as Purified (Rabbit, Recombinant Rabbit Monoclonal, clone AMH/6713R, Rabbit IgG, Unconjugated) and is designed to support common target-detection workflows after the on-page specifications.
Key elements and design rationale
- Target: Muellerian Inhibiting Factor
- Format: Purified
- Localization: Secreted
- Species reactivity: Human
- Applications (listed): IHC-P
- Conjugate: Unconjugated
- Clone and antibody class: Recombinant Rabbit Monoclonal, clone AMH/6713R, Rabbit IgG
Because antibody performance can depend on epitope context, sample preparation, and biological state, interpret signals using appropriate controls and orthogonal evidence when possible.
Biological background
Muellerian Inhibiting Factor is referenced in public gene/protein resources (e.g., UniProt and NCBI Gene), which provide curated names/synonyms, protein features, and pathway context. When designing assays, consider potential isoforms, post-translational modifications, and cell-type specific expression that may influence observed signal.
Research relevance and current trends
- Profiling Muellerian Inhibiting Factor expression across model systems, perturbations, and time points to support mechanistic hypotheses.
- Combining antibody-based detection with multi-omics or imaging readouts to link Muellerian Inhibiting Factor signal with phenotype.
- Using well-matched controls (isotype controls, genetic perturbations, or independent reagents) to strengthen interpretation of target-associated signal.
Common research applications
- IHC-P
Use the listed applications as a starting point and tailor experimental design to your sample type and readout requirements.
Notes for experimental interpretation
- Specificity considerations: closely related family members, isoforms, or PTMs can affect apparent specificity; confirm with independent approaches when critical.
- Controls: include negative controls and, when feasible, genetic or pharmacologic perturbations to support target attribution in your system.
- Species and sample context: differences in sequence, expression, fixation, or extraction conditions can change signal behavior across models.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
