| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| Target |
Compound Overview
Multi-kinase-IN-4 is a research-grade small molecule supplied by TargetMol.
Physical Properties
| Molecular Formula | C21H20ClFN2OS |
|---|---|
| Molecular Weight | 402.91 g/mol |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Multi-kinase-IN-4 (compound 5d) is a multi-targeted kinase inhibitor active against VEGFR2, EGFR, HER2, and CDK2, with respective IC50 values of 0.33, 0.22, 0.18, and 2.09 uM. It exhibits broad-spectrum anti-cancer properties in HepG2, MCF-7, MDA-231, and HeLa cell lines, with IC50 values ranging from 1.94 to 7.1 uM, and demonstrates lower toxicity in WI-38 cells (IC50 = 40.85 uM). Additionally, it induces apoptosis and causes S-phase cell cycle arrest in HepG2 cells, and holds potential for cancer research (1).
Target(s): VEGFR
Signaling pathway(s): Tyrosine Kinase/Adaptors, Angiogenesis
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
For currently available products, batch-specific purity data (HPLC chromatogram, NMR spectrum, and Certificate of Analysis) is accessible via the DataSheet link on the product page. For future or custom synthesis products, purity determination is conducted upon availability and published on the product page. Contact BioHippo for batch-specific CoA requests or custom synthesis enquiries.
Determining the amount based on solution clarity.1. If the prepared solution is clear, it can be prepared in a larger amount for one-time use and stored at 4°C. It is recommended to prepare the solution once a week, as prolonged storage may lead to loss of efficacy. 2. If the prepared solution is a suspension, it is recommended to prepare and use immediately each time.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
