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Compound Overview
N-trifluoroacetyl-β-alanyl chloride (CAS 87639-76-7) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 87639-76-7 |
|---|---|
| Molecular Formula | C5H5ClF3NO2 |
| Molecular Weight | 203.55 g/mol |
| SMILES | FC(F)(F)C(=O)NCCC(Cl)=O |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
N-trifluoroacetyl-beta-alanyl chloride is a cleavable linker utilized in the synthesis of antibody-drug conjugates (ADCs), which are bioconjugates formed by attaching drug molecules to antibodies.
Target(s): Others, ADC Linker
Signaling pathway(s): Others, Antibody-drug Conjugate/ADC Related
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Use a bath-type ultrasonic cleaner at standard cleaning frequency (37–40 kHz). Bath sonication is gentler than a probe sonicator and avoids sample overheating. Sonicate in 5–10 second intervals, checking solubility between pulses, for no more than 2–3 minutes total. Warm the bath to 37 °C if solubility remains poor.
Determining the amount based on solution clarity.1. If the prepared solution is clear, it can be prepared in a larger amount for one-time use and stored at 4°C. It is recommended to prepare the solution once a week, as prolonged storage may lead to loss of efficacy. 2. If the prepared solution is a suspension, it is recommended to prepare and use immediately each time.
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- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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