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Compound Overview
N3-PEG3-VC-PAB-MMAF (CAS 2757277-32-8) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 2757277-32-8 |
|---|---|
| Molecular Formula | C66H105N13O17 |
| Molecular Weight | 1352.62 g/mol |
| SMILES | (CH)((CH)(C(N(CH)(CC1=CC=CC=C1)C(O)=O)=O)C)(OC)(C)2(N(C(C(CH)((CH)(N(C… |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
N3-PEG3-VC-PAB-MMAF (Comp T-88-5) is a drug-linker conjugate for antibody-drug conjugates (ADCs) that comprises the ADC linker N3-PEG3-VC-PAB and the microtubule-disrupting agent MMAF (1). This click chemistry reagent boasts an Azide group enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) with Alkyne-bearing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) with compounds presenting DBCO or BCN groups.
Target(s): Others, Drug-Linker Conjugates for ADC
Signaling pathway(s): Antibody-drug Conjugate/ADC Related, Others
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Use a bath-type ultrasonic cleaner at standard cleaning frequency (37–40 kHz). Bath sonication is gentler than a probe sonicator and avoids sample overheating. Sonicate in 5–10 second intervals, checking solubility between pulses, for no more than 2–3 minutes total. Warm the bath to 37 °C if solubility remains poor.
mg/mL (milligrams per milliliter) and mM (millimolar = millimoles per liter) are two concentration units for the same solution. To convert: mM = (mg/mL × 1000) / MW (g/mol). For example, for a compound with MW = 350 g/mol: 1 mg/mL = 1000/350 = 2.86 mM. Use the molar concentration calculator on the TargetMol website for quick conversions.
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- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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