| Field | Specification |
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| Alternative names | Nav1.8, SCN10A, Scn10a, PN3, mPN3, Sns, SNS, Peripheral nerve sodium channel 3, Pn3 (gene name), Sensory neuron sodium channel, Sodium channel protein type 10 subunit alpha, Sodium channel protein type X alpha subunit, Voltage-gated sodium channel alpha subunit Nav1.8 |
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| Immunogen | Fusion protein amino acids 1724-1956 of rat Nav1.8 |
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Nav1.8 is a tetrodotoxin-resistant voltage-gated sodium channel encoded by the SCN10A gene and is selectively expressed in peripheral sensory neurons, particularly nociceptors. It is critical for the transmission of noxious stimuli and contributes to the upstroke of action potentials in pain pathways.
Nav1.8 is implicated in inflammatory and neuropathic pain, and its selective expression outside the central nervous system makes it a promising target for analgesic development. Unlike other sodium channels, Nav1.8 remains active at lower temperatures, supporting its role in cold-induced pain.
While not directly linked to central neurodegeneration, chronic pain and peripheral nerve dysfunction are increasingly recognized as contributors to cognitive decline and neuroinflammation. Targeting Nav1.8 may therefore have indirect benefits in managing neurodegenerative disease symptoms.
1 µg/ml of SMC-342 was sufficient for detection of Nav1.8 in 10 µg of COS cell lysate transiently expressing Nav1.8 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
Cite this product varies by variant:
- SMC-342D — Size: 100 ug: Nav1.8 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-342D, RRID: AB_2183852)
- SMC-342D-A390 — Size: 100 ug: Nav1.8 Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-342D-A390, RRID: AB_2700686)
- SMC-342D-A488 — Size: 100 ug: Nav1.8 Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-342D-A488, RRID: AB_2700687)
- SMC-342D-A594 — Size: 100 ug: Nav1.8 Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-342D-A594, RRID: AB_2700689)
- SMC-342D-APC — Size: 100 ug: Nav1.8 Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-342D-APC, RRID: AB_2700695)
- SMC-342D-BI — Size: 100 ug: Nav1.8 Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-342D-BI, RRID: AB_2700696)
- SMC-342D-FITC — Size: 100 ug: Nav1.8 Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-342D-FITC, RRID: AB_2700697)
- SMC-342D-HRP — Size: 100 ug: Nav1.8 Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-342D-HRP, RRID: AB_2700698)
- SMC-342D-PCP — Size: 100 ug: Nav1.8 Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-342D-PCP, RRID: AB_2700700)
- SMC-342D-RPE — Size: 100 ug: Nav1.8 Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-342D-RPE, RRID: AB_2700701)
- SMC-342S — Size: 12 ug: Nav1.8 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SMC-342S, RRID: AB_2183852)
Nav1.8 (SCN10A) is a tetrodotoxin-resistant voltage-gated sodium channel expressed mainly in peripheral sensory neurons, where it is central to pain signaling.
It is a Mouse monoclonal (clone S134, IgG2a) antibody.
This antibody is validated for Western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF). It detects a band at approximately 220 kDa. Optimal dilutions should be determined by the end user for each application.
Predicted/tested reactivity: human, mouse, rat, and monkey. Confirm reactivity for your species and sample type with appropriate controls.
No. This antibody is for in vitro research use only (RUO); it is not intended for diagnostic or therapeutic use in humans or animals.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
2. Dray A., Read S.J (2007) Arthritis Res. Ther. 9(3): 212.
3. Samuels M.E., teMorshe R.H., Lynch M.E., Drenth J.P. (2008) Mol Pain. 4: 21.
