| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | E.coli-derived human NAV3 recombinant protein (Position: K9-D1417) was used as the immunogen for the NAV3 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
NAV3 Antibody / Neuron navigator 3 is a anti-NAV3 Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human.
Key elements and design rationale
- Target: NAV3
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): WB, ELISA
Biological background
NAV3 localizes primarily to neuronal growth cones and extending axons, where it influences the assembly and organization of cytoskeletal networks required for directional growth. It interacts with signaling molecules involved in cytoskeletal regulation, including Rho GTPases and kinases that modulate actin-microtubule coordination. Beyond its developmental roles, NAV3 contributes to cytoskeletal remodeling in mature neurons and glial cells, supporting plasticity and response to injury.
The NAV3 antibody is used in neuroscience and developmental biology research to study axon formation, neuronal polarity, and migration. Western blot analysis identifies a 250 kilodalton band corresponding to NAV3, while immunofluorescence reveals punctate and filamentous staining along axons and dendritic processes. This antibody enables detailed visualization of cytoskeletal organization and neuronal network formation.
Altered NAV3 expression is associated with neurodevelopmental disorders, epilepsy, and gliomas, where disrupted cytoskeletal control affects cell morphology and migration. Additionally, NAV3 has been linked to wound healing and skin differentiation, as its expression is upregulated during keratinocyte migration. The NAV3 antibody provides a robust tool for analyzing cytoskeletal guidance mechanisms and neuronal development.
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- ELISA: support antibody-based quantification in assay formats where applicable.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
