| Field | Specification |
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| Target | |
| Alternative names | NCC, SLC12A3, SCYL1, CKb10, MCP-4, MGC17134, NCC-1, NCC1, SCYA13, CK-beta-10, Monocyte chemoattractant protein 4, Monocyte chemotactic protein 4, New CC chemokine 1, Small inducible cytokine A13, Small inducible cytokine subfamily A (Cys-Cys) member 13, Chemokine (C-C) |
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| Applications | |
| Immunogen | Produced against a synthetic peptide mapping to a segment of rat NCC (amino acids 74-95), N-terminal |
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The Na⁺-Cl⁻ co-transporter (NCC), primarily expressed in the distal convoluted tubule of the kidney, is a thiazide-sensitive transporter critical for sodium and chloride reabsorption. While traditionally studied in renal physiology and hypertension, emerging evidence suggests that NCC may also play a role in neurodegenerative disease through its influence on systemic electrolyte balance and neuronal excitability.
NCC is activated by phosphorylation and regulated by signaling pathways involving SGK1 and WNK kinases. Dysregulation of NCC activity can alter extracellular potassium and sodium levels, indirectly affecting neuronal membrane potential and synaptic transmission. Additionally, NCC expression has been detected in non-renal tissues, including the lens and possibly the brain, suggesting broader physiological roles.
In neurodegenerative contexts, electrolyte imbalance and altered ion transport are known contributors to neuronal dysfunction and glial activation. NCC-mediated sodium handling may influence neuroinflammatory responses and oxidative stress, particularly in conditions such as Alzheimer’s disease and vascular dementia. Furthermore, thiazide diuretics targeting NCC have been associated with cognitive effects, underscoring the transporter’s potential relevance in brain health.
Understanding NCC’s extrarenal functions may reveal novel mechanisms linking ion transport to neurodegeneration and offer new therapeutic avenues for modulating neuronal homeostasis.
1 µg/ml of SPC-402 was sufficient for detection of NCC3 in 10 µg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Cite this product varies by variant:
- SPC-402D — Size: 100 ug: NCC Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-402D, RRID: AB_10641430)
- SPC-402D-A390 — Size: 100 ug: NCC Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-402D-A390, RRID: AB_2704522)
- SPC-402D-A488 — Size: 100 ug: NCC Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-402D-A488, RRID: AB_2704523)
- SPC-402D-A594 — Size: 100 ug: NCC Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-402D-A594, RRID: AB_2704525)
- SPC-402D-APC — Size: 100 ug: NCC Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-402D-APC, RRID: AB_2704531)
- SPC-402D-BI — Size: 100 ug: NCC Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-402D-BI, RRID: AB_2704532)
- SPC-402D-FITC — Size: 100 ug: NCC Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-402D-FITC, RRID: AB_2704533)
- SPC-402D-HRP — Size: 100 ug: NCC Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-402D-HRP, RRID: AB_2704534)
- SPC-402D-PCP — Size: 100 ug: NCC Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-402D-PCP, RRID: AB_2704536)
- SPC-402D-RPE — Size: 100 ug: NCC Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-402D-RPE, RRID: AB_2704537)
- SPC-402S — Size: 12 ug: NCC Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-402S, RRID: AB_10641430)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
2. Tiwari S., et al. (2009) Am J Nephrol. 30(6): 554-562.
3. Chee K.N., Vorontsova I., Lim J.C., Kistler J. and Donaldson P.J. (2010) Mol Vis. 16:800-812.
