| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 2-{(3-cyano-4-(4-methylphenyl)-6-oxo-1,4 |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
Necrostatin-34 (CAS 375835-43-1) is a research-grade small molecule supplied by TargetMol.
Alternative names: 2-{(3-cyano-4-(4-methylphenyl)-6-oxo-1,4
Physical Properties
| CAS Number | 375835-43-1 |
|---|---|
| Molecular Formula | C18H16N4O2S2 |
| Molecular Weight | 384.48 g/mol |
| SMILES | C(N)C=1C(CC(=O)NC1SCC(NC2=NC=CS2)=O)C3=CC=C(C)C=C3 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Necrostatin-34 (2-{(3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.
Target(s): RIP kinase
Signaling pathway(s): NF-kappab, Apoptosis
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Insoluble impurities, which do not affect the product activity, are recommended to filter out or remove. We will investigate to confirm whether the impurity was introduced during packaging or if it is inherent to the product itself.
For normal mice, the concentration of DMSO should be kept below 10%. For nude mice, transgenic mice, or mice with weak tolerance, the concentration of DMSO should be kept below 2%. For inhibitors being used for the first time, it is recommended to perform a solvent-negative control experiment to confirm that the solvent has no nonspecific effects on the animals.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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