| Field | Specification |
|---|---|
| Mfr No | |
| Accession Number | |
| Alternative Names | Sodium / Hydrogen Exchanger 3, SLC9A3, Na+/H+ exchanger 3, isoform 3, Solute carrier family 9 member 3, NHE3MGC126720, MGC126718, solute carrier family 9 (sodium/hydrogen exchanger) member 3, NHE-3, Na(+)/H(+) exchanger 3, Sodium/hydrogen exchanger 3 |
| Cellular Localization | |
| Clonality | |
| Concentration | |
| Host | |
| Immunogen | Synthetic peptide mapping to AA 809 to 831 of rat sequence |
| Product Type | |
| Reactivity | |
| Shipping | |
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| Target |
Sodium-hydrogen exchanger 3 (NHE3), encoded by SLC9A3, is a membrane-bound transporter that mediates the electroneutral exchange of intracellular H+ for extracellular Na+. While primarily studied in renal and intestinal physiology, emerging evidence suggests NHE3 may influence neurodegenerative processes through its role in pH regulation, ion homeostasis, and cellular signaling. NHE3 is regulated by phosphorylation via kinases such as PKA, SGK1, and CK2, and its dysregulation may contribute to altered neuronal excitability and glial function. Aberrant NHE3 activity could exacerbate neuroinflammation and oxidative stress, both of which are implicated in Alzheimer’s disease and other neurodegenerative disorders. Understanding NHE3’s role in the brain may reveal novel therapeutic targets for modulating ionic balance and neuroinflammatory responses in neurodegeneration.
1 µg/ml of SPC-400 was sufficient for detection of HNE3 in 10 µg of rat kidney tissue lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Cite this product varies by variant:
- SPC-400D — Size: 100 ug: NHE3 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-400D, RRID: AB_10643557)
- SPC-400D-A390 — Size: 100 ug: NHE3 Antibody: ATTO 390 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-400D-A390, RRID: AB_2704488)
- SPC-400D-A488 — Size: 100 ug: NHE3 Antibody: ATTO 488 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-400D-A488, RRID: AB_2704489)
- SPC-400D-A594 — Size: 100 ug: NHE3 Antibody: ATTO 594 (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-400D-A594, RRID: AB_2704491)
- SPC-400D-APC — Size: 100 ug: NHE3 Antibody: APC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-400D-APC, RRID: AB_2704497)
- SPC-400D-BI — Size: 100 ug: NHE3 Antibody: Biotin (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-400D-BI, RRID: AB_2704498)
- SPC-400D-FITC — Size: 100 ug: NHE3 Antibody: FITC (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-400D-FITC, RRID: AB_2704499)
- SPC-400D-HRP — Size: 100 ug: NHE3 Antibody: HRP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-400D-HRP, RRID: AB_2704500)
- SPC-400D-PCP — Size: 100 ug: NHE3 Antibody: PerCP (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-400D-PCP, RRID: AB_2704502)
- SPC-400D-RPE — Size: 100 ug: NHE3 Antibody: RPE (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-400D-RPE, RRID: AB_2704503)
- SPC-400S — Size: 12 ug: NHE3 Antibody (StressMarq Biosciences | Victoria, BC CANADA, Catalog# SPC-400S, RRID: AB_10643557)
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
2. Dynia D.W., Steinmetz A.G. and Kocinsky H.S. (2010) Am J Physoil Renal Physiol. 298(3): F745-F753.
