| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | A synthesized peptide derived from human NR2C2 / TR4 was used as the immunogen for the NR2C2 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
NR2C2 Antibody / Nuclear receptor subfamily 2 group C member 2 / TR4 is a anti-NR2C2 Rabbit antibody Recombinant Rabbit Monoclonal clone 31N37 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.
Key elements and design rationale
- Target: NR2C2
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 31N37, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): WB
Biological background
NR2C2 antibody is widely applied in endocrinology, neuroscience, and cancer research. In reproductive tissues, NR2C2 regulates steroidogenesis and germ cell development. In the central nervous system, it contributes to neuronal differentiation and brain development. Altered NR2C2 expression has been linked to prostate cancer, glioma, and developmental disorders. By detecting NR2C2, researchers can investigate how nuclear receptors integrate hormonal signals with transcriptional control across diverse tissues.
Western blot assays detect NR2C2 protein bands in nuclear fractions, while immunohistochemistry highlights expression in reproductive and neural tissues. Immunofluorescence maps NR2C2 localization to the nucleus, consistent with its role as a DNA binding transcription factor. These applications make NR2C2 antibody versatile for research into nuclear receptor biology.
NR2C2 interacts with corepressors, coactivators, and chromatin remodeling complexes, positioning it as a hub in transcriptional networks. It regulates genes controlling lipid metabolism, energy balance, and differentiation. By applying NR2C2 antibody, scientists can evaluate how transcriptional circuits controlled by nuclear receptors contribute to health and disease.
NR2C2 antibody from
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
