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| Immunogen | A synthesized peptide derived from human NUP155 was used as the immunogen for the NUP155 antibody. |
| Isotype | |
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| Reactivity | |
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Overview
NUP155 Antibody / Nucleoporin 155 is a anti-NUP155 Rabbit antibody Recombinant Rabbit Monoclonal clone 30N56 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human.
Key elements and design rationale
- Target: NUP155
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 30N56, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): WB
Biological background
NUP155 antibody is commonly used in studies of nucleocytoplasmic transport and nuclear architecture. The protein is particularly important for maintaining nuclear envelope stability and selective transport of cargo. Defects in NUP155 impair nuclear pore complex assembly and disrupt gene regulation by altering nucleo cytoplasmic communication.
The antibody is suitable for western blotting, immunohistochemistry, immunofluorescence, and flow cytometry. In western blot assays, NUP155 antibody recognizes protein bands corresponding to the expected molecular weight. Immunohistochemistry shows localization at the nuclear envelope, while immunofluorescence provides fine resolution of subnuclear distribution. These applications make NUP155 antibody versatile for research in molecular biology and cell signaling.
Clinical research has linked NUP155 mutations to atrial fibrillation and sudden cardiac death. The connection underscores the importance of nuclear pore complexes beyond basic transport, showing that nuclear envelope proteins contribute to cardiac rhythm and function. By detecting NUP155, researchers can explore how mutations or altered expression influence disease progression.
Nucleoporins, including NUP155, are increasingly recognized as regulators of gene expression. Their roles extend to chromatin organization, DNA repair, and signal transduction. Dysregulation of nucleoporins has been linked to cancer and developmental disorders. NUP155 antibody provides a tool to investigate how nuclear pore function impacts diverse biological processes.
NUP155 antibody from
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
