| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | OD 36 hydrochloride |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
OD36 hydrochloride (CAS 2387510-88-3) is a research-grade small molecule supplied by TargetMol.
Alternative names: OD 36 hydrochloride
Physical Properties
| CAS Number | 2387510-88-3 |
|---|---|
| Molecular Formula | C16H16Cl2N4O2 |
| Molecular Weight | 367.23 g/mol |
| SMILES | Cl.ClC=1C=C2OCCOCCN=C3C=CN4N=CC(C(C1)=C2)=C4N3 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficiently to the ATP pocket of the ALK2 kinase and effectively antagonizes mutant ALK2 signaling and osteogenic differentiation.OD36 hydrochloride targets ALK2. OD36 hydrochloride targets ALK2 with a KD of 37 nM.
Target(s): RIP kinase, ALK
Signaling pathway(s): NF-kappab, Angiogenesis, Apoptosis, Tyrosine Kinase/Adaptors
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
It is not recommended to store DMSO stock solutions at room temperature. Once the stock solution is prepared, aliquot into single-use volumes and store at −20 °C (or −80 °C for sensitive compounds). Room-temperature storage accelerates chemical degradation and moisture uptake. When ready to use, thaw an aliquot at room temperature, use immediately, and avoid repeated freeze-thaw cycles.
Melted ice packs are generally not a concern for solid powder compounds, as the short transit period at ambient temperature does not typically affect compound integrity or potency. Powder form is inherently more stable than solution form during temperature fluctuations. Upon receipt, transfer the compound to −20 °C immediately. If you observe color change, odor, or physical changes, contact BioHippo for quality investigation.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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