| Field | Specification |
|---|---|
| Activity | |
| Alternative Names | NSC 347901 |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
Oltipraz (CAS 64224-21-1) is a research-grade small molecule supplied by TargetMol.
Alternative names: NSC 347901
Physical Properties
| CAS Number | 64224-21-1 |
|---|---|
| Molecular Formula | C8H6N2S3 |
| Molecular Weight | 226.34 g/mol |
| SMILES | CC1=C(SSC1=S)C=2C=NC=CN2 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H: quinone oxidoreductase 1 (NQO1). The induction of detoxification enzymes enhances the detoxification of certain cancer-causing agents, thereby enhancing their elimination and preventing carcinogen-induced DNA damages. Although the exact mechanism through which the anti-angiogenesis effect remains to be fully elucidated, oltipraz maybe able to modulate the expression of a number of angiogenic factors, thereby blocking the sustained and focal neovascularization in multiple tumor cell types.
Target(s): Reverse Transcriptase, HIF, HIF/HIF Prolyl-Hydroxylase, HIV Protease, Nrf2
Signaling pathway(s): Microbiology/Virology, Angiogenesis, Immunology/Inflammation, Metabolism, Chromatin/Epigenetic, Proteases/Proteasome
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
When solubility is listed as < 1 mg/mL, the compound dissolves to less than 1 mg per milliliter in water at 25 °C, pH 7.4. Such compounds require an organic co-solvent such as DMSO to prepare a concentrated stock, which is then diluted into aqueous assay buffer. For cell-based assays, keep the final DMSO concentration below 0.1% (v/v) to avoid solvent-induced cytotoxicity.
For currently available products, batch-specific purity data (HPLC chromatogram, NMR spectrum, and Certificate of Analysis) is accessible via the DataSheet link on the product page. For future or custom synthesis products, purity determination is conducted upon availability and published on the product page. Contact BioHippo for batch-specific CoA requests or custom synthesis enquiries.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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