| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
ONO-8711 (CAS 216158-34-8) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 216158-34-8 |
|---|---|
| Molecular Formula | C22H30ClNO4S |
| Molecular Weight | 440.00 g/mol |
| SMILES | C(NS(=O)(=O)C1=C(C)C=C(Cl)C=C1)(CH)2(CH)(/C=CCCCC(O)=O)C3CCC2CC3 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
ONO-8711 is a potent and selective competitive antagonist of EP1 receptor with Kis of 0.6 nM and 1.7 nM for human and mouse EP1, respectively. ONO-8711 effectively reduces tumor incidence and multiplicity in mouse models of colon, breast, and oral cancer (1).
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
mg/mL (milligrams per milliliter) and mM (millimolar = millimoles per liter) are two concentration units for the same solution. To convert: mM = (mg/mL × 1000) / MW (g/mol). For example, for a compound with MW = 350 g/mol: 1 mg/mL = 1000/350 = 2.86 mM. Use the molar concentration calculator on the TargetMol website for quick conversions.
Yes — TargetMol inhibitors can be used in cell-based and in vitro experiments. Prepare a DMSO stock, then dilute into cell culture medium to the desired working concentration, keeping DMSO ≤ 0.1% (v/v) to avoid solvent toxicity. Note that not all compounds have published data for every cell line or assay system; in such cases, perform a dose-response experiment with appropriate positive and vehicle controls to validate efficacy in your specific model.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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