| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | E.coli-derived human OSCAR recombinant protein (Position: D19-V282) was used as the immunogen for the OSCAR antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
OSCAR Antibody / Osteoclast-associated immunoglobulin-like receptor is a anti-OSCAR Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), ELISA with listed reactivity in Human, Mouse, Rat.
Key elements and design rationale
- Target: OSCAR
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): WB, ELISA
Biological background
Functionally, OSCAR antibody identifies a 287-amino-acid protein containing two extracellular immunoglobulin-like domains and a short cytoplasmic tail. OSCAR acts as a costimulatory receptor on osteoclast precursors, promoting NFATc1 activation and osteoclastogenesis in response to RANKL and ITAM signaling. It also mediates immune cell activation, cytokine secretion, and antigen presentation in monocytes and dendritic cells.
The OSCAR gene is located on chromosome 19q13.4 and is primarily expressed in bone-resorbing osteoclasts, macrophages, and dendritic cells. Its activity links the immune and skeletal systems, contributing to bone remodeling and inflammation-associated bone loss.
Pathologically, elevated OSCAR expression has been observed in rheumatoid arthritis, osteoporosis, and periodontitis, where excessive osteoclast activation leads to bone degradation. Research using OSCAR antibody supports studies in bone metabolism, immune signaling, and inflammatory disease mechanisms.
OSCAR antibody is validated for western blotting, immunohistochemistry, and flow cytometry to detect immunoreceptors involved in osteoclast and immune cell function.
Structurally, Osteoclast-associated immunoglobulin-like receptor contains extracellular Ig-like domains that interact with collagen and intracellular motifs that recruit signaling adapters via Fc receptor gamma chains. This antibody enables examination of OSCAR's role in osteoclast activation and immune crosstalk.
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- ELISA: support antibody-based quantification in assay formats where applicable.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
