| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | E.coli-derived mouse Osmr recombinant protein (Position: E673-Q968) was used as the immunogen for the Osmr antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
Osmr Antibody / Oncostatin M receptor is a anti-Osmr Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as ELISA, Western blot (WB), Flow cytometry (FACS) with listed reactivity in Mouse, Rat.
Key elements and design rationale
- Target: Osmr
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): ELISA, WB, FACS
Biological background
OSMR is encoded by the OSMR gene on human chromosome 5p13.1. The protein is approximately 100 kilodaltons and contains an extracellular cytokine-binding domain, a single transmembrane helix, and a cytoplasmic tail harboring signaling motifs that recruit JAK kinases and STAT transcription factors. OSMR is expressed in a wide range of cell types, including epithelial cells, fibroblasts, and immune cells, where it mediates diverse biological responses to inflammatory cues.
An OSMR antibody detects a 100-200 kilodalton band by western blot and exhibits membrane and perinuclear staining under immunofluorescence. Ligand binding induces heterodimerization of OSMR with gp130 or IL31RA, leading to phosphorylation of JAK1 and JAK2 and subsequent activation of STAT3 and STAT5 transcription factors. These pathways regulate genes involved in cell proliferation, differentiation, and extracellular matrix remodeling.
In the immune system, OSMR signaling modulates macrophage activation, Th2 cytokine production, and inflammation resolution. In epithelial tissues, OSMR promotes wound healing and regeneration but, when overactivated, contributes to chronic inflammation and fibrosis. Dysregulation of OSMR expression has been linked to psoriasis, asthma, and several cancers, where it enhances tumor progression through paracrine cytokine signaling.
Because of its dual role in inflammation and tissue regeneration, OSMR represents an important biomarker and therapeutic target in immune-mediated and neoplastic diseases.
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Flow cytometry: quantify target-positive populations and signal shifts at single-cell resolution.
- ELISA: support antibody-based quantification in assay formats where applicable.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
