| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | C16-PAF |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
PAF (C16) (CAS 74389-68-7) is a research-grade small molecule supplied by TargetMol.
Alternative names: C16-PAF
Physical Properties
| CAS Number | 74389-68-7 |
|---|---|
| Molecular Formula | C26H54NO7P |
| Molecular Weight | 523.68 g/mol |
| SMILES | (CH)(COP(OCC(N+)(C)(C)C)(=O)(O-))(COCCCCCCCCCCCCCCCC)OC(C)=O |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
PAF (C16) is a potent MAPK and MEK/ERK activator that induces increased vascular permeability. PAF (C16) (PAF (C16)) is a platelet-activating factor, a phospholipid-derived mediator and a ligand for PAF G protein-coupled receptor (PAFR). PAF (C16) has shown anti-apoptotic and anti-inflammatory activity in vitro, inhibiting Caspase-dependent apoptosis by interacting with its receptor (PAF-R) to perform cell signaling.
Target(s): Endogenous Metabolite, MEK, ERK, MAPK
Signaling pathway(s): MAPK, Metabolism
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Use a bath-type ultrasonic cleaner rather than a high-intensity ultrasonic disruptor. Bath sonicators provide gentle, uniform agitation appropriate for dissolving solid compounds without generating cavitation damage or excessive heat. Ensure the solvent tube is fully submerged and use short sonication pulses of 5–10 seconds.
Yes — TargetMol inhibitors can be used in cell-based and in vitro experiments. Prepare a DMSO stock, then dilute into cell culture medium to the desired working concentration, keeping DMSO ≤ 0.1% (v/v) to avoid solvent toxicity. Note that not all compounds have published data for every cell line or assay system; in such cases, perform a dose-response experiment with appropriate positive and vehicle controls to validate efficacy in your specific model.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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