| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | E.coli-derived human PARVG recombinant protein (Position: M1-E280) was used as the immunogen for the PARVG antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
PARVG Antibody / Gamma Parvin is a anti-PARVG Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Flow cytometry (FACS), ELISA with listed reactivity in Human, Mouse, Rat.
Key elements and design rationale
- Target: PARVG
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): WB, FACS, ELISA
Biological background
Functionally, PARVG antibody identifies a 372-amino-acid cytoplasmic protein containing two calponin-homology (CH) domains that mediate actin binding and integrin interaction. PARVG participates in integrin-mediated adhesion signaling, influencing cell spreading, migration, and cytoskeletal dynamics. It contributes to mechanotransduction pathways in endothelial and immune cells.
The PARVG gene is located on chromosome 22q13.31 and is expressed in leukocytes, vascular smooth muscle cells, and skeletal muscle. PARVG regulates integrin activation and focal adhesion turnover, playing a key role in immune cell motility and vascular integrity.
Pathologically, altered PARVG expression has been linked to cancer cell migration, vascular remodeling, and inflammatory responses. Dysregulation of PARVG contributes to defective adhesion signaling and cytoskeletal organization. Research using PARVG antibody supports studies in integrin signaling, cytoskeletal remodeling, and vascular biology.
PARVG antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect cytoskeletal and adhesion-associated proteins.
Structurally, Gamma-parvin contains CH1 and CH2 domains that facilitate actin binding and ILK-PINCH complex formation. This antibody aids in analyzing PARVG's function in integrin-linked cytoskeletal networks and adhesion regulation.
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Flow cytometry: quantify target-positive populations and signal shifts at single-cell resolution.
- ELISA: support antibody-based quantification in assay formats where applicable.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
