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| Target |
Compound Overview
PD-L1-IN-2 (CAS 2894733-91-4) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 2894733-91-4 |
|---|---|
| Molecular Formula | C33H38N4O6 |
| Molecular Weight | 586.68 g/mol |
| SMILES | O=C(OC(C)(C)C)NC1=CC=CC(=C1)C(=O)NC2=NC(=C(N2C)CC3=CC=C(OC)C(OC)=C3)CC… |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
PD-L1-IN-2, a Naamidine J derivative, serves as a promising antineoplastic immunomodulator by hindering PD-L1 activity. In vivo studies indicate that it suppresses PD-L1 expression and amplifies tumor-infiltrating T-cell response, thus exerting anticancer effects. This compound is particularly utilized in the investigation of colorectal cancer (1).
Target(s): PD-1/PD-L1
Signaling pathway(s): Immunology/Inflammation, Apoptosis, Cell Cycle/Checkpoint
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Use a bath-type ultrasonic cleaner at standard cleaning frequency (37–40 kHz). Bath sonication is gentler than a probe sonicator and avoids sample overheating. Sonicate in 5–10 second intervals, checking solubility between pulses, for no more than 2–3 minutes total. Warm the bath to 37 °C if solubility remains poor.
For currently available products, batch-specific purity data (HPLC chromatogram, NMR spectrum, and Certificate of Analysis) is accessible via the DataSheet link on the product page. For future or custom synthesis products, purity determination is conducted upon availability and published on the product page. Contact BioHippo for batch-specific CoA requests or custom synthesis enquiries.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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