| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | PLX-3397 |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
Pexidartinib (CAS 1029044-16-3) is a research-grade small molecule supplied by TargetMol.
Alternative names: PLX-3397
Physical Properties
| CAS Number | 1029044-16-3 |
|---|---|
| Molecular Formula | C20H15ClF3N5 |
| Molecular Weight | 417.81 g/mol |
| SMILES | C(C=1C=2C(NC1)=NC=C(Cl)C2)C=3C=CC(NCC=4C=CC(C(F)(F)F)=NC4)=NC3 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Pexidartinib (PLX-3397) is a capsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity.
Target(s): CSF-1R, FLT, c-Fms, Apoptosis, c-Kit
Signaling pathway(s): Angiogenesis, Tyrosine Kinase/Adaptors, Apoptosis
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Try the following steps: (1) warm the DMSO solvent to 37–50 °C before adding the compound; (2) vortex vigorously for 30 seconds then bath-sonicate for 1–2 minutes; (3) if still undissolved, prepare a more dilute stock. Note that maximum solubility values are reference conditions — actual solubility can vary with temperature, solvent lot, and compound batch. Contact BioHippo support if dissolution problems persist.
For normal mice, the concentration of DMSO should be kept below 10%. For nude mice, transgenic mice, or mice with weak tolerance, the concentration of DMSO should be kept below 2%. For inhibitors being used for the first time, it is recommended to perform a solvent-negative control experiment to confirm that the solvent has no nonspecific effects on the animals.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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