| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| Target |
Compound Overview
PI3Kδ-IN-12 is a research-grade small molecule supplied by TargetMol.
Physical Properties
| Molecular Formula | C20H15Cl2N5O3 |
|---|---|
| Molecular Weight | 444.27 g/mol |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
PI3Kdelta-IN-12 (compound 13), a PI3Kdelta inhibitor with a pIC50 of 5.8, exhibits differential binding affinities with pKi values of 8.0 for PI3Kdelta, 6.5 for PI3Kgamma, 6.4 for PI3Kbeta, and 6.7 for PI3Kalpha. This compound is utilized in researching chronic respiratory conditions, including asthma and chronic obstructive pulmonary disease (COPD) (1).
Target(s): PI3K
Signaling pathway(s): PI3K/Akt/mTOR signaling
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Melted ice packs are generally not a concern for solid powder compounds, as the short transit period at ambient temperature does not typically affect compound integrity or potency. Powder form is inherently more stable than solution form during temperature fluctuations. Upon receipt, transfer the compound to −20 °C immediately. If you observe color change, odor, or physical changes, contact BioHippo for quality investigation.
Yes, our inhibitors can be used for animal/in vivo experiments. However, some compounds may not have literature supporting their use in animal experiments. In such cases, we cannot guarantee efficacy.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
