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Compound Overview
PLK1/p38γ-IN-1 (CAS 2418614-81-8) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 2418614-81-8 |
|---|---|
| Molecular Formula | C21H26ClN3O2 |
| Molecular Weight | 387.90 g/mol |
| SMILES | C(=O)((CH)1(CH)(OCCC1)C2=CN(CC)N=C2)N3C=4C(=CC(Cl)=CC4)CCCC3 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
PLK1/p38gamma-IN-1 (compound 14) serves as a dual inhibitor targeting both PLK1 and p38gamma kinases, effectively suppressing the proliferation of human hepatocellular carcinoma and hepatoblastoma cell lines in vitro (1).
Target(s): p38 MAPK
Signaling pathway(s): MAPK
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Use a bath-type ultrasonic cleaner at standard cleaning frequency (37–40 kHz). Bath sonication is gentler than a probe sonicator and avoids sample overheating. Sonicate in 5–10 second intervals, checking solubility between pulses, for no more than 2–3 minutes total. Warm the bath to 37 °C if solubility remains poor.
Melted ice packs are generally not a concern for solid powder compounds, as the short transit period at ambient temperature does not typically affect compound integrity or potency. Powder form is inherently more stable than solution form during temperature fluctuations. Upon receipt, transfer the compound to −20 °C immediately. If you observe color change, odor, or physical changes, contact BioHippo for quality investigation.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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