| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | LY2140023 hydrochloride |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
Pomaglumetad methionil hydrochloride (CAS 635318-26-2) is a research-grade small molecule supplied by TargetMol.
Alternative names: LY2140023 hydrochloride
Physical Properties
| CAS Number | 635318-26-2 |
|---|---|
| Molecular Formula | C12H19ClN2O7S2 |
| Molecular Weight | 402.87 g/mol |
| SMILES | N(C((CH)(CCSC)N)=O)(C)1(C(O)=O)(C)2((C)((CH)2C(O)=O)(S(=O)(=O)C1)(H))(… |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Pomaglumetad methionine hydrochloride (LY2140023 hydrochloride) is a methionine prodrug of LY404039 with oral activity. LY404039 is a selective mGlu2/3 receptor agonist. Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) has research value in schizophrenia.
Target(s): GluR
Signaling pathway(s): Neuroscience
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
When solubility is listed as < 1 mg/mL, the compound dissolves to less than 1 mg per milliliter in water at 25 °C, pH 7.4. Such compounds require an organic co-solvent such as DMSO to prepare a concentrated stock, which is then diluted into aqueous assay buffer. For cell-based assays, keep the final DMSO concentration below 0.1% (v/v) to avoid solvent-induced cytotoxicity.
Try the following steps: (1) warm the DMSO solvent to 37–50 °C before adding the compound; (2) vortex vigorously for 30 seconds then bath-sonicate for 1–2 minutes; (3) if still undissolved, prepare a more dilute stock. Note that maximum solubility values are reference conditions — actual solubility can vary with temperature, solvent lot, and compound batch. Contact BioHippo support if dissolution problems persist.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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