| Field | Specification |
|---|---|
| Mfr No | |
| Enzyme Type | |
| Expression System | |
| Form | Lyophilized |
| Formulation | |
| Product Type | |
| Purity | |
| Source | Escherichia Coli. |
| Species | |
| Storage | |
| Target |
Product Description
Paraoxonase-1 (68-124) Human Recombinant
Background
Paraoxonase 1 also known as PON1takes part in the detoxification of organophosphate insecticides such as parathion. PON1 is related to high-density lipoprotein (HDL) in the plasma and takes an important part in lipid metabolism and antioxidant defense. PON1 was first known for its ability to hydrolyze organophosphates and protect against oxidative stress. PON1 reduces oxidative stress by preventing the oxidation of lipids in LDL particles, which is extremely important in mitigating atherosclerosis and other cardiovascular diseases. PON1 has an anti-inflammatory effects which help reduce inflammatory markers in different disease states. PON1 takes part in cholesterol metabolism, influencing the stability and formation of HDL particles, which are vital for lipid transport and reverse cholesterol efflux.
Specifications
| Purity | Greater than 90% as determined by SDS-PAGE. |
|---|---|
| Formulation | Each mg was lyophilized with 1xPBS, 0.4% SDS and 4mM DTT. |
| Storage | Store lyophilized PON1 at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Expression System | Escherichia Coli. |
