| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide, AP-24534 |
| Cas No. | |
| Form | Yellow powder |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | May be dissolved in DMSO (50 mg/ml); or Ethanol (25 mg/ml, warm) |
| Source | Synthetic |
| Storage |
Ponatinib is a multi-targeted tyrosine kinase inhibitor developed for resistant forms of leukemia. It inhibits BCR-ABL as well as kinases associated with VEGFR and FGFR signaling.
Although not traditionally associated with neuroscience, Ponatinib’s inhibition of angiogenic and growth factor pathways has potential implications in brain tumor research and neurovascular disorders. Its ability to cross-inhibit multiple signaling cascades may also be relevant in neurodegenerative diseases where aberrant kinase activity contributes to neuronal dysfunction or glial proliferation.
Details:
May be harmful by inhalation, ingestion, or skin absorption.
May cause eye, skin, or respiratory system irritation.
Ponatinib (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-588)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
