| Field | Specification |
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| Mfr No | |
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| Host | |
| Immunogen | A synthesized peptide derived from human PRMT7 was used as the immunogen for the PRMT7 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
PRMT7 Antibody / Protein arginine methyltransferase 7 is a anti-PRMT7 Rabbit antibody Recombinant Rabbit Monoclonal clone 29P93 supplied in Liquid format. Recommended for workflows such as Western blot (WB) with listed reactivity in Human, Mouse, Rat.
Key elements and design rationale
- Target: PRMT7
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 29P93, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): WB
Biological background
PRMT7 antibody is widely applied in epigenetics, RNA biology, and cancer research. By detecting PRMT7, researchers can explore how symmetric arginine dimethylation influences chromatin regulation and cellular signaling. PRMT7 activity has been linked to stem cell pluripotency, DNA repair, stress responses, and immune regulation. In embryonic stem cells, PRMT7 maintains self renewal by repressing differentiation associated genes. In DNA repair, PRMT7 modifies proteins such as histone H4, contributing to recruitment of repair complexes.
Applications of PRMT7 antibody include western blotting, immunohistochemistry, immunofluorescence, and ELISA. Western blotting detects PRMT7 protein in nuclear and cytoplasmic fractions, immunohistochemistry maps expression in tissues such as testis and skeletal muscle, and immunofluorescence highlights dynamic localization in response to stress. These assays provide powerful approaches for analyzing PRMT7 biology across systems.
PRMT7 dysregulation contributes to cancer, immune dysfunction, and developmental syndromes. Amplification or overexpression of PRMT7 has been observed in breast, lung, and hematologic cancers, where it alters gene expression and promotes survival. Loss of PRMT7 function has been associated with intellectual disability syndromes, reflecting its role in neural development. By applying PRMT7 antibody, scientists can investigate how balanced methyltransferase activity is required for normal physiology.
Therapeutically, PRMT7 is a candidate drug target. Inhibitors of PRMT7 are under development to modulate arginine methylation in cancer and immune diseases. Detection of PRMT7 expression by antibody based assays provides biomarkers for preclinical studies and therapeutic development.
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
