| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | (1E,4S,4aR,5R,6aS,9aR)-5-(acetyloxy)-1-[(di-2-propen-1-ylamino)methylene]-4,4a,5,6,6a,8,9,9a-octahydro-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-cyclopenta[5,6]naphtho[1,2-c]pyran-2,7,10(1H)-trione |
| Cas No. | |
| Form | Crystalline solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO at 200 mg/ml; soluble in ethanol at 200 mg/ml; very poorly soluble in water |
| Source | Synthetic |
| Storage |
PX 866 is a wortmannin derivative that inhibits phosphoinositide 3-kinase (PI3K), blocking downstream signaling involved in cell growth and motility. In neuroscience, PX 866 is used to study the PI3K/Akt pathway, which regulates neuronal survival, metabolism, and autophagy. Its ability to inhibit tumor growth and cell migration is leveraged in neuro-oncology and neurodegeneration research to explore the effects of PI3K inhibition on neural cell function and disease progression.
Acute Toxicity:
Inhalation, Category 4
Acute Toxicity:
Oral, Category 4
Acute Toxicity:
Skin, Category 4
Skin Corrosion/Irritation, Category 2
Serious Eye Damage/Eye Irritation, Category 2
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
H332:
Harmful if inhaled.
H302:
Harmful if swallowed.
H312:
Harmful in contact with skin.
H315:
Causes skin irritation.
H319:
Causes serious eye irritation.
P261:
Avoid breathing {dust/fume/gas/mist/vapours/spray}.
P264:
Wash {hands} thoroughly after handling.
P280:
- Wear {protective gloves/protective clothing/eye protection/face protection}.
- P362+364: Take off contaminated clothing and wash it before reuse.
- P304+340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P312:
- Call a {POISON CENTER/doctor/...} if you feel unwell.
- P301+312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P330:
- Rinse mouth.
- P302+352: IF ON SKIN: Wash with plenty of soap and water.
P321:
- Specific treatment {see ... on this label}.
- P332+313: If skin irritation occurs, get medical advice/attention.
- P305+351+338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P337+313: If eye irritation persists, get medical advice/attention.
PX 866 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-471)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. Gwak H.S., et al. (2011). Int. J. Cancer. 128(4): 787–796.
