QNZ 46

Product details

• Chemical name: 4-[6-methoxy-2-[(E)-2-(3-nitrophenyl)ethenyl]-4-oxoquinazolin-3-yl]benzoic acid.
• Also known as: 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)quinazolinyl]benzoic acid
• CAS number: 1237744-13-6
• Molecular formula: C24H17N3O6.
• Purity: >99%
• Concentration: 1-50 µM.
• Form: Lyophilized Powder
• Solubility: Soluble in DMSO up to 10 mM with gentle warming. Centrifuge all products before handling (10000 x g 5 min).
• Reconstitution: Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
• Shipping: Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
• Target: NMDA receptors
• Source: Synthetic
• Activity: QNZ-46 is a potent, noncompetitive NMDA receptor antagonist, exhibiting significant selectivity for NR2D and NR2C-containing receptors (IC50 = 3 µM and 6 µM, respectively) over NR2A and NR2B-containing receptors (IC50 = 229 µM and >300 µM, respectively)1.
• Alternative names: 4-[6-Methoxy-2-[(1E)-2-(3-nitrophenyl)ethenyl]-4-oxo-3(4H)quinazolinyl]benzoic acid

Scientific background

QNZ 46 is a potent and selective antagonist of GluN2C/GluN2D-containing N-methyl-D-aspartate (NMDA) receptors. It inhibits NMDA receptor function in a non-competitive and voltage-independent manner1. The compound demonstrates IC50 value of 3.9 and 7.1 µM for NR2D and NR2C containing receptors respectively and 182 and over 193 µM for NR2A and NR2B-containing receptors1.NMDA receptors are heterotetrameric channels formed by the assembly of two obligatory GluN1 and two GluN2/GluN3 subunits. They play an important role in a variety of cellular processes and physiological functions such as, synaptic plasticity, learning and memory formation, addiction and stroke, and are important components in glutamate excitotoxicity. NMDA receptors are also involved in many neurodegenerative conditions including Alzheimer's disease2.

Lead time: 1-2 Business Days

Country of origin: Israel/IL

Applications key

Application key: FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay.

Bioassay tested: Yes

• SDS (PDF)

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