Quisqualic Acid

Quisqualic acid is a potent agonist of AMPA and metabotropic glutamate receptors, used to induce excitotoxicity in experimental models. In neuroscience, it is employed to study glutamate-mediated neuronal injury, synaptic transmission, and neurodegeneration. Quisqualic acid triggers calcium influx and oxidative stress, mimicking pathological conditions observed in stroke and neurodegenerative diseases. Its application helps elucidate the role of glutamatergic signaling in neuronal survival and the development of excitotoxic damage. Quisqualic acid is instrumental in evaluating neuroprotective agents and understanding excitatory neurotransmission in the brain.

Classification: Not WHMIS controlled.

Safety Phrases:

• S22 - Do not breathe dust.
• S24/25 - Avoid contact with skin and eyes.
• S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.

Hazard statements:

• H302 + H312 Harmful if swallowed or in contact with skin
• H332 Harmful if inhaled.

Precautionary statements:

• P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
• P264 Wash skin thoroughly after handling.
• P270 Do not eat, drink or smoke when using this product.
• P271 Use only outdoors or in a well-ventilated area.
• P280 Wear protective gloves/ protective clothing.
• P301 + P312 IF SWALLOWED: Call a POISON CENTER or doctor/ physician if you feel unwell.
• P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
• P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
• P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
• P322 Specific measures (see supplemental first aid instructions on this label).
• P330 Rinse mouth.
• P363 Wash contaminated clothing before reuse.
• P501 Dispose of contents/ container to an approved waste disposal plant.

Quisqualic Acid (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-418)

Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.

• Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
• Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
• Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
• QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
• Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity

To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).

Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close equivalents, or discuss custom synthesis with the right QC documentation (RUO).