| Field | Specification |
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| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | A synthesized peptide derived from human RAC3 was used as the immunogen for the RAC3 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
RAC3 Antibody / Ras related C3 botulinum toxin substrate 3 is a anti-RAC3 Rabbit antibody Recombinant Rabbit Monoclonal clone 32R19 supplied in Liquid format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC) with listed reactivity in Human, Mouse, Rat.
Key elements and design rationale
- Target: RAC3
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 32R19, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): WB, IHC
Biological background
RAC3 antibody is widely used in cancer research, neuroscience, and cell signaling studies. RAC3 promotes lamellipodia formation and actin remodeling, driving cell migration and invasion. In cancer, elevated RAC3 expression has been linked to tumor progression, metastasis, and therapy resistance. By detecting RAC3, researchers can study how GTPase signaling influences cytoskeletal regulation and oncogenic transformation.
Western blot assays detect RAC3 protein in diverse tissues and cell lines. Immunohistochemistry reveals expression in epithelial tissues and tumor samples, while immunofluorescence highlights subcellular distribution at lamellipodia and cell junctions. ELISA applications enable quantitative assessment of RAC3 expression across experimental samples.
RAC3 also plays roles in neuronal development and plasticity. In the brain, RAC3 regulates axon guidance, dendritic spine formation, and synaptic signaling. Dysregulation of RAC3 has been associated with intellectual disability, psychiatric disorders, and neurodegeneration. By applying RAC3 antibody, scientists can evaluate how GTPase signaling contributes to neuronal structure and function.
Beyond the nervous system and cancer, RAC3 participates in immune responses, angiogenesis, and wound healing. Its broad impact across tissues makes it an important target for basic and translational research. The antibody therefore serves as a versatile reagent for exploring cytoskeletal and signaling pathways across biology.
RAC3 antibody from
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Immunohistochemistry: map target signal in tissue context and compare regions/phenotypes.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
