| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | Cell cycle-associated protein 1 (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105 GPIAP1) (GPIP137) (M11S1) (RNG105) |
| Conjugate | |
| Endotoxin Level | |
| Expression System | |
| Form | Liquid or Lyophilized powder |
| Function | |
| Molecular Weight | |
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| Protein Length | |
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| Reconstitution | |
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| UniProt # |
Overview
This Recombinant Protein provides recombinant CAPRIN1 from Homo sapiens (Human), produced in Baculovirus (region 2-709aa). It is commonly used as a defined reagent for assay development, binding studies, and mechanistic research (RUO).
Key elements and design rationale
- Region: 2-709aa (domain boundaries can affect binding/activity readouts).
- Expression host: Baculovirus (may differ from native PTMs/processing).
- Tag(s): His (supports purification/detection; consider tag effects in controls).
Biological background
Also reported as Cell cycle-associated protein 1 (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105 GPIAP1) (GPIP137) (M11S1) (RNG105). May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs.
Research relevance and current trends
- Use of recombinant standards to improve assay calibration and cross-study comparability.
May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Binds directly and selectively to MYC and CCND2 RNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs.
Common research applications
- Standard curve or spike-in reference for quantitative assays involving CAPRIN1
- Binding and specificity benchmarking for detection reagents (conceptual)
Notes for experimental interpretation
- Recombinant constructs may not capture all native isoforms or PTMs.
- Consider tag- or host-related effects when interpreting binding or activity.
- Use appropriate blanks and matrix/control concepts to separate signal from background.
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