| Field | Specification |
|---|---|
| Mfr No | |
| Accession Number | |
| Alternative Names | Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1; EGFR;ERBB; ERBB1; HER1 |
| Conjugate | |
| Endotoxin Level | |
| Expression System | |
| Form | Lyophilized |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Reconstitution | |
| Shipping | |
| Species | |
| Storage | |
| Target |
Background
EGFR is a target studied in oncology & angiogenesis research. The sections below provide general scientific background to support interpretation-focused decision making.
- Gene/target: EGFR
- Alternative names: Epidermal growth factor receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
- Accession: P00533
- Species context: Human
Sequence/region note: Recombinant constructs are often produced as defined fragments or domains. This product corresponds to an expressed region annotated as Leu25-Ser645, which may represent a specific portion of the full-length protein used for controlled studies.
Biological role and pathway context
EGFR is a receptor-associated target commonly studied for how extracellular cues are translated into intracellular signaling outputs. Receptor behavior can be influenced by ligand availability, co-receptors, clustering, and regulated trafficking, which together shape downstream pathway activity.
In Oncology & Angiogenesis research, EGFR is often discussed within themes such as mechanistic biology studies, pathway-level interpretation, comparative model systems. These themes can help frame interpretation of molecular measurements in relation to broader biological programs.
Receptor signaling is often embedded in feedback loops and cross-talk with parallel pathways. As a result, changes in receptor abundance or state may reflect altered expression, shedding, or compartmentalization rather than a single causal step.
Related molecules considered in interpretation may include cognate ligands, adaptor proteins, kinases/phosphatases that relay signals, and downstream transcriptional markers that report pathway activation.
Expression and regulation
Expression of EGFR can be regulated at multiple levels, including transcriptional control, mRNA stability, translation, and protein turnover. Many targets also exhibit context-dependent expression across tissues or model systems and may respond dynamically to stress, growth cues, immune stimulation, or metabolic state. When comparing datasets, consider species, cell type, stimulus, and time course.
Isoforms and molecular forms
Many proteins exist as alternative isoforms or processed forms, and post-translational modifications (for example, phosphorylation, glycosylation, acetylation, or proteolytic processing) can alter localization, interactions, or activity. When interpreting results involving EGFR, consider whether studies distinguish full-length protein from specific domains or fragments, and whether modification states are relevant to the biological question.
Why it matters in research
- Pathway interpretation: helps connect molecular changes to network-level hypotheses in oncology & angiogenesis studies.
- Comparative analysis: supports cross-condition or cross-model comparisons when nomenclature and context are aligned.
- Systems context: often interpreted alongside related pathway components to distinguish direct effects from secondary changes.
Disease and process relevance
Depending on the target, published studies may report associations between EGFR and disease mechanisms or physiological processes. Such associations are typically context dependent and are best interpreted alongside complementary markers and functional readouts, rather than as standalone evidence.
What is the purity of Recombinant Human EGFR (C-6His) (Human)?
How should Recombinant Human EGFR (C-6His) (Human) be stored?
What expression system was used to produce this protein?
What is the molecular weight of this protein?
What are the shipping conditions?
Is this protein approved for clinical or in vitro diagnostic use?
Can I request a custom size, tag variant, or formulation?
Can’t Find What You’re Looking For? We can help you source the best match or customize a recombinant protein solution for your study. Options may include species (human/mouse/rat), protein region/domain (full-length vs fragment), tag or label (His/GST/FLAG/biotin/fluorescent), expression system (E. coli/HEK293/insect), purity grade, formulation (buffer, carrier-free, glycerol-free), activity/functional validation (binding or enzymatic assays), endotoxin level (low-endotoxin for cell-based work), mutants/variants (point mutations, isoforms), and bulk or custom packaging. Click Talk to a Scientist to submit a request form, email us at support@biohippo.com, or explore our Research Services for additional support. Our team will be in contact with you shortly.
