| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | Cell-scattering factor 140 kDa subunit (CSF 140 kDa subunit) (Epiligrin subunit gamma) (Kalinin subunit gamma) (Kalinin/nicein/epiligrin 100 kDa subunit) (Ladsin 140 kDa subunit) (Laminin B2t chain) (Laminin-5 subunit gamma) (Large adhesive scatter factor 140 kDa subunit) (Nicein subunit gamma) (LAMB2T) (LAMNB2) |
| Conjugate | |
| Endotoxin Level | |
| Expression System | |
| Form | Liquid or Lyophilized powder |
| Molecular Weight | |
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| Reconstitution | |
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| UniProt # |
Overview
This Recombinant Protein provides recombinant LAMC2 from Homo sapiens (Human), produced in E.coli (region 417-588aa). It is commonly used as a defined reagent for assay development, binding studies, and mechanistic research (RUO).
Key elements and design rationale
- Region: 417-588aa (domain boundaries can affect binding/activity readouts).
- Expression host: E.coli (may differ from native PTMs/processing).
- Tag(s): His, GST (supports purification/detection; consider tag effects in controls).
Biological background
Also reported as Cell-scattering factor 140 kDa subunit (CSF 140 kDa subunit) (Epiligrin subunit gamma) (Kalinin subunit gamma) (Kalinin/nicein/epiligrin 100 kDa subunit) (Ladsin 140 kDa subunit) (Laminin B2t chain) (Laminin-5 subunit gamma) (Large adhesive scatter factor 140 kDa subunit) (Nicein subunit gamma) (LAMB2T) (LAMNB2). Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells.
Research relevance and current trends
- Quantitative mapping of ligand/receptor signaling to downstream phospho- and transcriptional programs.
- Use of recombinant standards to improve assay calibration and cross-study comparability.
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ladsin exerts cell-scattering activity toward a wide variety of cells, including epithelial, endothelial, and fibroblastic cells
Common research applications
- Standard curve or spike-in reference for quantitative assays involving LAMC2
- Binding interaction studies (e.g., SPR/BLI or plate-based binding formats)
- Cell-based stimulation studies with downstream marker readouts (conceptual)
Notes for experimental interpretation
- Recombinant constructs may not capture all native isoforms or PTMs.
- Consider tag- or host-related effects when interpreting binding or activity.
- Use appropriate blanks and matrix/control concepts to separate signal from background.
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