| Field | Specification |
|---|---|
| Mfr No | |
| Alternative Names | Pigment epithelium-derived factor,PEDF, Serpin-F1, SerpinF1, EPC-1, EPC1, PIG35. |
| Cellular Localization | |
| Concentration | |
| Expression System | |
| Form | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation | |
| Product Type | |
| Protein Length | |
| Protein Size | |
| Purity | |
| Solubility | It is recommended to reconstitute the lyophilized PEDF in sterile 18M-cm H 2 O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Source | Escherichia Coli. |
| Species | |
| Storage | |
| Target |
Recombinant Human Pigment Epithelium-Derived Factor is supplied as a recombinant protein for in vitro research use.
Background
PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. PEDF is a 50,000 dalton glycoprotein created and secreted in many tissues all the way through the body. A key component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. Additionally, PEDF is capable to inhibit the activity of angiogenic factors such as VEGF and FGF-2. The neuro-protective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recognition of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities associate it as a potential therapeutic agent for the treatment of vasculature related neurodegenerative diseases such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF in addition has the potential to be functional in the treatment of various angiogenesis-related diseases including a number of cancers.
About PEDF Human Also known as “Pigment Epithelium-Derived Factor” or “SERPINF1,” PEDF is a multifunctional protein found in vertebrates. It has anti-tumorigenic, anti-angiogenic, and neurotrophic functions. Currently, it’s being researched as a candidate for treatment for several conditions, including heart disease and cancer. What’s the Function of PEDF Human Recombinant? PEDF is created/secreted in several tissues across the body. It has a unique anti-angiogenic action because of its induction of apoptosis in proliferating endothelial cells. Also, PEDF can inhibit many angiogenic factors, including VEGF and FGF-2. PEDF-R is currently the only known signaling receptor to be used by a serpin family member. What’s the Application of PEDF Human Recombinant? This version of PEDF is produced in E. Coli. It’s a single, non-glycosylated, polypeptide chain that contains 400 amino acids. It has a molecular mass of 44.5 kDa, and it’s purified by proprietary chromatographic techniques. The main purpose of PEDF human recombinant is for research. It has the potential to become a potential treatment for different angiogenesis-related diseases, including various cancers. Moreover, it can become crucial during the recovery from vasculature- related neurodegenerative illness. Such a discovery could be revolutionary for the world, which is why more research is needed to determine the effect of this non-inhibitory serpin on the body.
Product format
Provided as a recombinant protein suitable for in vitro workflows such as binding studies, screening, and assay development. Refer to the specifications table for expression format and molecular properties.
What is the purity of Recombinant Human Pigment Epithelium-Derived Factor (Human)?
What buffer / formulation is this protein supplied in?
How should Recombinant Human Pigment Epithelium-Derived Factor (Human) be stored?
What expression system was used to produce this protein?
Is this protein approved for clinical or in vitro diagnostic use?
Can I request a custom size, tag variant, or formulation?
Can’t Find What You’re Looking For? We can help you source the best match or customize a recombinant protein solution for your study. Options may include species (human/mouse/rat), protein region/domain (full-length vs fragment), tag or label (His/GST/FLAG/biotin/fluorescent), expression system (E. coli/HEK293/insect), purity grade, formulation (buffer, carrier-free, glycerol-free), activity/functional validation (binding or enzymatic assays), endotoxin level (low-endotoxin for cell-based work), mutants/variants (point mutations, isoforms), and bulk or custom packaging. Click Talk to a Scientist to submit a request form, email us at support@biohippo.com, or explore our Research Services for additional support. Our team will be in contact with you shortly.
