| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 300 kDa nuclear matrix antigen (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) (KIAA0324) (SRL300) (SRM300) |
| Conjugate | |
| Endotoxin Level | |
| Expression System | |
| Form | Liquid or Lyophilized powder |
| Function | |
| Molecular Weight | |
| Product Type | |
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| Purity | |
| Reconstitution | |
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| UniProt # |
Overview
This Recombinant Protein provides recombinant SRRM2 from Homo sapiens (Human), produced in Baculovirus (region 1666-2089aa). It is commonly used as a defined reagent for assay development, binding studies, and mechanistic research (RUO).
Key elements and design rationale
- Region: 1666-2089aa (domain boundaries can affect binding/activity readouts).
- Expression host: Baculovirus (may differ from native PTMs/processing).
- Tag(s): His, Myc (supports purification/detection; consider tag effects in controls).
Biological background
Also reported as 300 kDa nuclear matrix antigen (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (SR-related nuclear matrix protein of 300 kDa) (Ser/Arg-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (Tax-responsive enhancer element-binding protein 803) (TaxREB803) (KIAA0324) (SRL300) (SRM300). Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity). Binds to RNA.
Research relevance and current trends
- Use of recombinant standards to improve assay calibration and cross-study comparability.
Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate. Binds to RNA.
Common research applications
- Standard curve or spike-in reference for quantitative assays involving SRRM2
- Binding and specificity benchmarking for detection reagents (conceptual)
Notes for experimental interpretation
- Recombinant constructs may not capture all native isoforms or PTMs.
- Consider tag- or host-related effects when interpreting binding or activity.
- Use appropriate blanks and matrix/control concepts to separate signal from background.
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