| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | E.coli-derived human RERE recombinant protein (Position: D109-H1037) was used as the immunogen for the RERE antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
RERE Antibody / Arginine-glutamic acid dipeptide repeats protein is a anti-RERE Rabbit antibody Polyclonal (rabbit origin) supplied in Lyophilized format. Recommended for workflows such as Western blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Flow cytometry (FACS), ELISA with listed reactivity in Human. Reported localization: Nuclear.
Key elements and design rationale
- Target: RERE
- Antibody details: Rabbit, Polyclonal (rabbit origin), isotype Rabbit IgG
- Format: Lyophilized
- Applications (as listed): WB, IHC, ICC, IF, FACS, ELISA
Biological background
RERE serves as both a coactivator and corepressor for nuclear receptors such as retinoic acid receptor (RAR) and histone deacetylases (HDACs), linking transcriptional regulation with epigenetic modification. It plays an essential role in retinoic acid signaling, a pathway required for proper embryonic tissue differentiation. Through its interactions with transcription factors and epigenetic complexes, RERE controls gene expression patterns that direct neuronal patterning, heart formation, and eye morphogenesis. Its chromatin-association properties make it a central player in gene regulatory networks that define developmental outcomes.
Mutations or deletions in the RERE gene are associated with 1p36 deletion syndrome and RERE-related neurodevelopmental disorders, which cause developmental delay, hypotonia, and congenital malformations. Functional studies in model organisms show that loss of RERE disrupts neural crest migration, cardiac outflow tract formation, and craniofacial development. The protein's regulatory activity within retinoic acid signaling links it to both morphogenetic and metabolic control during embryogenesis.
At the molecular level, RERE interacts with HDAC1/2, p300/CBP, and other transcriptional repressors to modulate chromatin accessibility. These interactions determine whether RERE acts as a transcriptional activator or repressor depending on context. RERE also influences p53-dependent apoptosis and tumor suppression, highlighting its dual role in development and cancer. Reduced RERE expression has been observed in certain malignancies, suggesting a protective function against tumorigenesis.
Structurally, RERE contains an N-terminal Atrophin-1 domain, several arginine/glutamic acid-rich repeats, and nuclear localization signals that facilitate chromatin binding. Its modular architecture allows multiple protein interactions, and its Atrophin-like region contributes to transcriptional repression. Evolutionarily, RERE is conserved among vertebrates and classified within the atrophin family of transcriptional regulators, known for controlling gene silencing and differentiation. RERE is also implicated in pathways such as retinoic acid signaling and chromatin remodeling, reflecting its multifunctional nature.
Immunohistochemical staining using RERE antibody demonstrates nuclear localization in neurons, cardiac myocytes, and developing epithelia. The RERE antibody from
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Immunofluorescence: visualize subcellular distribution and cell-to-cell heterogeneity.
- Immunohistochemistry: map target signal in tissue context and compare regions/phenotypes.
- Flow cytometry: quantify target-positive populations and signal shifts at single-cell resolution.
- ELISA: support antibody-based quantification in assay formats where applicable.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Polyclonal antibodies recognize multiple epitopes, which can broaden the epitope footprint and may increase sensitivity in some contexts.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
