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Compound Overview
RIPK3-IN-4 (CAS 2304617-58-9) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 2304617-58-9 |
|---|---|
| Molecular Formula | C24H18BrFN4O3S |
| Molecular Weight | 541.39 g/mol |
| SMILES | O=C(NC=1C=CC=C(Br)C1)NC2=CC(OC=3C=CC=4N=C(SC4C3)NC(=O)C5CC5)=CC=C2F |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
RIPK3-IN-4 (Compound 42) is a RIPK3 inhibitor that mitigates necroptosis, inflammatory responses, and HK-2 cell damage. It alleviates acute kidney injury by attenuating Cisplatin- and I/R-induced kidney damage, along with associated inflammatory responses and necroptosis (1).
Target(s): RIP kinase
Signaling pathway(s): Apoptosis, NF-kappab
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
mg/mL (milligrams per milliliter) and mM (millimolar = millimoles per liter) are two concentration units for the same solution. To convert: mM = (mg/mL × 1000) / MW (g/mol). For example, for a compound with MW = 350 g/mol: 1 mg/mL = 1000/350 = 2.86 mM. Use the molar concentration calculator on the TargetMol website for quick conversions.
Due to the small pack, the powder may be highly dispersed during shipping due to static electricity and may adhere to the vial. Please centrifuge and add an appropriate solvent to fully dissolve the product and prepare the stock solution.
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