| Field | Specification |
|---|---|
| Activity | |
| Alternative Names | BRL49653 |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
Rosiglitazone (CAS 122320-73-4) is a research-grade small molecule supplied by TargetMol.
Alternative names: BRL49653
Physical Properties
| CAS Number | 122320-73-4 |
|---|---|
| Molecular Formula | C18H19N3O3S |
| Molecular Weight | 357.43 g/mol |
| SMILES | C(C1SC(=O)NC1=O)C2=CC=C(OCCN(C)C3=CC=CC=N3)C=C2 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Rosiglitazone (BRL49653) is a PPARgamma agonist, TRPC5 activator, and TRPM3 inhibitor with oral activity. Rosiglitazone is also a hypoglycemic agent and a thiazolidinedione insulin sensitizer.
Target(s): Autophagy, TRP/TRPV Channel, PPAR, Ferroptosis
Signaling pathway(s): Apoptosis, DNA Damage/DNA Repair, Membrane transporter/Ion channel, Autophagy, Metabolism
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Product quality is assured — all TargetMol compounds undergo structural confirmation by ¹H NMR and purity determination by HPLC before release. If no effect is observed, consider the following: (1) the IC50 in literature may have been determined in a different cell line or assay format; (2) solubility or cell permeability may be limiting at the tested concentration; (3) establish a concentration gradient (e.g., 0.1–30 µM) tailored to your specific experimental system. A positive control compound with a known cellular effect in your assay is recommended.
Centrifuge the closed vial at 3000 rpm for 1–2 minutes to consolidate the powder at the bottom. For electrostatically charged powders, briefly warm the vial to room temperature and allow it to equilibrate before opening. Then add the appropriate solvent directly onto the powder and vortex before sonicating. Avoid tapping the vial vigorously, as this can generate fine powder aerosol.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
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