| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione |
| Cas No. | |
| Form | White to off-white solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (3 mg/ml) or DMF (10 mg/ml) |
| Source | Synthetic |
| Storage |
Rosiglitazone Maleate is a high-affinity agonist of peroxisome proliferator-activated receptor gamma (PPARγ), with an EC50 of 43 nM. While primarily developed as an insulin sensitizer for type 2 diabetes, Rosiglitazone has gained attention in neurodegenerative disease research, particularly Alzheimer’s disease. Activation of PPARγ has been shown to modulate neuroinflammation, enhance mitochondrial function, and improve insulin signaling in the brain—factors implicated in cognitive decline. Rosiglitazone has demonstrated the ability to rescue memory deficits in preclinical Alzheimer’s models, positioning it as a candidate for therapeutic repurposing. Its dual role in metabolic regulation and neuroprotection makes it a valuable compound in the study of neurodegeneration and brain insulin resistance.
Classification: Caution: Substance not yet fully tested.
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
Rosiglitazone Maleate (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-379)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
2. McMorran M., and Vu D. (2001) CMAJ. 165(1): 82-3, 86-7.
3. Malinowski J.M. & Bolesta S. (2000) Clin. Ther. 22(10): 1151-68.
4. Cheng-Lai A., & Levine A. (2000) Heart Dis. 2(4): 326-33.
5. Knock G.A., et al. (1999) Eur. J. Pharmacol. 368(1): 103-9.
6. Balfour J.A., & Plosker G.L. (1999) Drugs. 57(6): 921-30.
7. Parks D.J., et al. (1998) Bioorg. Med. Chem. Lett. 8(24): 3657-8. 8. Escribano L., et al. (2010) Neuropyschopharmacology. 35, 1593-1604.
