| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | SB 202190 (hydrochloride) |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
SB 202190 hydrochloride (CAS 350228-36-3) is a research-grade small molecule supplied by TargetMol.
Alternative names: SB 202190 (hydrochloride)
Physical Properties
| CAS Number | 350228-36-3 |
|---|---|
| Molecular Formula | C20H15ClFN3O |
| Molecular Weight | 367.80 g/mol |
| SMILES | Cl.FC=1C=CC(=CC1)C=2NC(=NC2C=3C=CN=CC3)C=4C=CC(O)=CC4 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
SB 202190 hydrochloride is a selective and cell-permeable p38 MAPK inhibitor that inhibits p38alpha and p38beta2 (IC50=50/100 nM). SB 202190 hydrochloride has anti-tumor activity and can also induce the differentiation of human embryonic stem cells into cardiomyocytes.
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
When solubility is listed as < 1 mg/mL, the compound dissolves to less than 1 mg per milliliter in water at 25 °C, pH 7.4. Such compounds require an organic co-solvent such as DMSO to prepare a concentrated stock, which is then diluted into aqueous assay buffer. For cell-based assays, keep the final DMSO concentration below 0.1% (v/v) to avoid solvent-induced cytotoxicity.
Melted ice packs are generally not a concern for solid powder compounds, as the short transit period at ambient temperature does not typically affect compound integrity or potency. Powder form is inherently more stable than solution form during temperature fluctuations. Upon receipt, transfer the compound to −20 °C immediately. If you observe color change, odor, or physical changes, contact BioHippo for quality investigation.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
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