| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Alternative Names | 4-Amino-[2',3'-bithiophene]-5-carboxamide |
| Cas No. | |
| Form | Yellow solid |
| Molecular Weight | |
| Product Type | |
| Purity | |
| Shipping | |
| SMILES | |
| Solubility | Soluble in DMSO (>25 mg/ml) |
| Source | Synthetic |
| Storage |
SC 514 is a selective and reversible inhibitor of IκB kinase 2 (IKKβ), a key regulator of the NF-κB signaling pathway. By blocking IKKβ activity, SC 514 prevents the phosphorylation and degradation of IκBα, thereby inhibiting NF-κB activation. In neurodegenerative disease research, SC 514 is used to explore the role of NF-κB in neuroinflammation, glial activation, and neuronal survival. Its >10-fold selectivity over other kinases such as JNK, p38, MK2, and ERK enhances its utility in dissecting inflammatory signaling in the brain. SC 514 is cell-permeable and is a valuable compound for studying therapeutic strategies targeting chronic inflammation in neurodegenerative disorders.
Classification: Acute toxicity, Oral (Category 3)
Safety Phrases:
- S22 - Do not breathe dust.
- S24/25 - Avoid contact with skin and eyes.
- S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Hazard statements:
H301 Toxic if swallowed
Precautionary statements:
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician
SC 514 (StressMarq Biosciences Inc., Victoria BC CANADA, Catalog # SIH-475)
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
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2. Baxter A., et al. (2004) Bioorganic Med. Chem. Letters. 14(11): 2817–2822.
