| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | A synthesized peptide derived from human SEC14L2 / TAP was used as the immunogen for the SEC14L2 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
SEC14L2 Antibody / SEC14-like protein 2 is a anti-SEC14L2 Rabbit antibody Recombinant Rabbit Monoclonal clone 31S32 supplied in Liquid format. Recommended for workflows such as Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Western blot (WB) with listed reactivity in Human, Mouse, Rat.
Key elements and design rationale
- Target: SEC14L2
- Antibody details: Rabbit, Recombinant Rabbit Monoclonal, clone 31S32, isotype Rabbit IgG
- Format: Liquid
- Applications (as listed): IF, IHC, ICC, WB
Biological background
SEC14 like protein 2 is primarily expressed in the liver, where it localizes to cytoplasmic and membrane compartments. Research using SEC14L2 antibody has demonstrated that it interacts with phosphatidylinositol and other lipids, potentially regulating availability of signaling molecules. In hepatocytes, SEC14 like protein 2 may act as a cofactor for lipid modifying enzymes, integrating lipid metabolism with cell signaling and homeostasis. Its conservation across species highlights an essential role in cellular lipid handling.
One of the most intriguing functions of SEC14 like protein 2 is its ability to support hepatitis C virus replication. Studies with SEC14L2 antibody have shown that expression of this protein allows hepatitis C virus to replicate efficiently in cell culture models that are otherwise nonpermissive. This has made SEC14 like protein 2 a focus of viral research, as its presence facilitates the assembly of viral replication complexes. Its role in host-virus interactions positions it as a potential antiviral target.
Beyond virology, SEC14 like protein 2 is associated with cancer biology and metabolic disease. Research using SEC14L2 antibody has suggested that altered expression influences lipid signaling pathways, contributing to tumorigenesis or metabolic dysfunction. Because lipid metabolism is tightly linked to growth control and energy balance, SEC14 like protein 2 may serve as a metabolic regulator in both health and disease.
SEC14L2 antibody is applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting confirms expression in liver tissues and cell lines, immunohistochemistry demonstrates tissue distribution, and immunofluorescence reveals cytoplasmic and membrane localization. These applications make SEC14L2 antibody versatile for metabolic and viral research.
By supplying validated SEC14L2 antibody reagents,
Research relevance and current trends
- Connecting protein-level changes to phenotype using orthogonal readouts (genetic perturbation, transcriptomics, imaging).
- Considering isoforms and post-translational regulation when interpreting protein-level changes.
- Comparing results across species and model systems with matched controls.
Common research applications
- Western blotting: compare relative abundance and activation-state changes across conditions.
- Immunofluorescence: visualize subcellular distribution and cell-to-cell heterogeneity.
- Immunohistochemistry: map target signal in tissue context and compare regions/phenotypes.
Interpret changes in signal alongside appropriate controls and, when relevant, in parallel with total-protein or pathway readouts.
Notes for experimental interpretation
- Signal can reflect expression level, isoform composition, and post-translational state; interpret results in the context of your model system and stimuli.
- Species differences and sample matrices can influence epitope recognition; prioritize matched controls and orthogonal confirmation when feasible.
Antibody notes: Monoclonal antibodies provide a defined epitope recognition profile that can support consistent comparisons across experiments.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
