| Field | Specification |
|---|---|
| Mfr No | |
| Clonality | |
| Host | |
| Immunogen | Amino acids KETIEIETQVPEKKK were used as the immunogen for this SGLT1 antibody. |
| Isotype | |
| Product Type | |
| Purity | |
| Reactivity | |
| Storage | |
| Target | |
| UniProt # |
Overview
SGLT1 Antibody / Sodium/glucose cotransporter 1 is an antibody targeting SGLT1, raised in Goat for protein detection and localization studies where these specifications are required.
Key elements and design rationale
- Target: SGLT1.
- Antibody identity: Polyclonal (goat origin); Goat Ig.
- Conjugate/label: Unconjugated (affects detection chemistry and multiplex compatibility).
- Format: Antigen affinity purified.
- Species reactivity: Human.
- Listed applications: IHC-P, ELISA (peptide) (refer to on-page specifications for application-specific guidance).
Biological background
Sodium/glucose cotransporter 1 / SGLT1 is primarily found in the small intestine and the kidneys, where it facilitates the transportation of glucose and sodium across cell membranes. In the intestines, SGLT1 helps in the absorption of glucose from the food we eat, ensuring that it enters the bloodstream and provides energy to our cells. In the kidneys, SGLT1 is involved in the reabsorption of glucose from the urine back into the bloodstream, preventing its wastage and ensuring that the body retains this valuable energy source. This function becomes particularly important in cases of high blood sugar levels, such as in diabetes, where the kidneys may excrete excess glucose in the urine.
Research relevance and current trends
- Comparative expression profiling across cell types, tissues, or perturbations (e.g., drug treatment, genetic editing, or differentiation).
- Subcellular localization and trafficking studies, including co-localization with pathway markers in microscopy-based assays.
- Integration of protein-level measurements with transcriptomics or proteomics to relate abundance to regulation and phenotype.
Common research applications
- Immunohistochemistry: researchers commonly compare relative signal levels across conditions and use appropriate negative/positive controls for interpretation.
- ELISA: researchers commonly compare relative signal levels across conditions and use appropriate negative/positive controls for interpretation.
Interpretation should account for antibody-dependent factors such as epitope accessibility, isoforms, and sample preparation differences across workflows.
Notes for experimental interpretation
- Isoforms and PTMs: many targets have multiple isoforms and post-translational modifications that can shift apparent signal or localization; interpret bands/signals accordingly.
- Epitope context: binding can depend on protein conformation and sample processing; region information in the title/immunogen can help anticipate what may be detected.
- Species differences: predicted or validated reactivity may vary by ortholog sequence and sample context; confirm in your model system.
- Control concepts: include negative controls (no-primary/isotype), and where possible genetic controls (KO/KD) or independent antibodies to strengthen conclusions.
Customization & Add-ons: Can’t find the antibody you need—or require a custom format for your assay? We can help you source the best match or support custom antibody solutions for diverse research needs, including species and isotype selection, conjugations and labeling (e.g., HRP/AP, biotin, fluorophores), purification grade options (Protein A/G, affinity purified), formulation preferences (buffer selection, carrier-free, glycerol-free), custom concentrations and aliquoting, low-endotoxin options for cell-based work, and application-focused QC/validation support (project dependent). Click Talk to a Scientist to submit a request, email us at support@biohippo.com, or explore our Research Services for additional support—our team will follow up with feasibility details and next steps.
