| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| Target |
Compound Overview
Sirt1/2-IN-2 (CAS 670267-73-9) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 670267-73-9 |
|---|---|
| Molecular Formula | C18H14N4O3S2 |
| Molecular Weight | 398.46 g/mol |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Sirt1/2-IN-2 (compound hsa55) serves as a dual inhibitor for SIRT1 with an IC50 of 1.8 uM and SIRT2 with an IC50 of 2.4 uM, respectively. It effectively inhibits p53 deacetylation while enhancing the acetylation of p53 and alpha-tubulin. The compound also promotes apoptosis and exhibits anti-proliferative effects on human leukemia cell lines (1).
Target(s): Sirtuin
Signaling pathway(s): Chromatin/Epigenetic, DNA Damage/DNA Repair
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Most small molecule inhibitors are not compatible with autoclaving (121 °C), which can cause thermal decomposition or loss of biological activity. For sterile cell-based experiments, filter-sterilize working solutions through a 0.2 µm membrane after dilution into aqueous buffer. Verify thermal stability in the DataSheet before applying any heat treatment.
Centrifuge the closed vial at 3000 rpm for 1–2 minutes to consolidate the powder at the bottom. For electrostatically charged powders, briefly warm the vial to room temperature and allow it to equilibrate before opening. Then add the appropriate solvent directly onto the powder and vortex before sonicating. Avoid tapping the vial vigorously, as this can generate fine powder aerosol.
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- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
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