| Field | Specification |
|---|---|
| Mfr No | |
| Activity | |
| Cas No. | |
| Molecular Weight | |
| Product Type | |
| Signaling Pathway | |
| SMILES | |
| Target |
Compound Overview
Sirt1/2-IN-3 (CAS 301313-42-8) is a research-grade small molecule supplied by TargetMol.
Physical Properties
| CAS Number | 301313-42-8 |
|---|---|
| Molecular Formula | C17H14ClNO4S |
| Molecular Weight | 363.82 g/mol |
| SMILES | COC1=CC=C(C=C1)S(=O)(=O)NC1=C2C=CC=CC2=C(O)C(Cl)=C1 |
| Form | Solid |
| Shipping | Room Temperature (RT) |
Biological Activity
Sirt1/2-IN-3 (compound PS9) serves as a dual inhibitor of SIRT1/2, exhibiting IC50 values of 1.4 uM (SIRT1) and 2.0 uM (SIRT2), respectively. This compound effectively inhibits p53 deacetylation while simultaneously elevating p53 and alpha-tubulin acetylation levels. Additionally, Sirt1/2-IN-3 promotes apoptosis and exhibits antiproliferative effects on human leukemia cell lines (1).
Target(s): Sirtuin
Signaling pathway(s): Chromatin/Epigenetic, DNA Damage/DNA Repair
Safety & Regulatory
For Research Use Only (RUO). Not for therapeutic, diagnostic, or clinical use. Wear appropriate PPE and consult the Safety Data Sheet (SDS) prior to handling.
Solubility data for each compound is provided on the TargetMol product page and DataSheet, listed as maximum solubility in DMSO and/or aqueous media (mg/mL and mM). For compounds not yet characterized, prepare a test dissolution at the intended stock concentration and visually confirm clarity before use. When preparing aqueous working solutions, always dilute from a DMSO stock and monitor for precipitation at your final assay concentration.
Yes — TargetMol inhibitors can be used in cell-based and in vitro experiments. Prepare a DMSO stock, then dilute into cell culture medium to the desired working concentration, keeping DMSO ≤ 0.1% (v/v) to avoid solvent toxicity. Note that not all compounds have published data for every cell line or assay system; in such cases, perform a dose-response experiment with appropriate positive and vehicle controls to validate efficacy in your specific model.
Need this compound in a format that drops straight into your assay? We can tailor formulation, chemistry, and documentation so your results stay consistent across runs and re-orders.
- Format options: solid or pre-dissolved solution (choose solvent), target concentration, aliquots, light/moisture-protected packaging
- Chemistry options: free base/acid vs salt forms, hydrate/solvate preference, stereoisomer control (single enantiomer or racemate), close analogs
- Add-on labels & handles: D/¹³C/¹⁵N isotopes (LC-MS/internal standards), azide/alkyne or other functional handles for conjugation
- QC & documentation: standard COA or enhanced analytical pack (HPLC/LC-MS/NMR), chiral purity, residual solvents, water content (KF), method-specific specs
- Scale & continuity: mg to gram scale, bulk pricing, lot reservation, repeat-order continuity
To quote quickly, tell us: compound name + CAS/structure (SMILES or mol file), intended assay context, solvent preference, salt/stereochemistry requirements, purity/QC level, and the amount (mg–g).
Can’t find the compound you’re looking for?
Send the CAS or structure and your specs. We can help source it, suggest close
equivalents, or discuss custom synthesis with the right QC documentation (RUO).
